Building capacity for dissemination and implementation research: One university’s experience

Abstract Background While dissemination and implementation (D&I) science has grown rapidly, there is an ongoing need to understand how to build and sustain capacity in individuals and institutions conducting research. There are three inter-related domains for capacity building: people, settings, and activities. Since 2008, Washington University in St. Louis has dedicated significant attention and resources toward building D&I research capacity. This paper describes our process, challenges, and lessons with the goal of informing others who may have similar aims at their own institution. Activities An informal collaborative, the Washington University Network for Dissemination and Implementation Research (WUNDIR), began with a small group and now has 49 regular members. Attendees represent a wide variety of settings and content areas and meet every 6 weeks for half-day sessions. A logic model organizes WUNDIR inputs, activities, and outcomes. A mixed-methods evaluation showed that the network has led to new professional connections and enhanced skills (e.g., grant and publication development). As one of four, ongoing, formal programs, the Dissemination and Implementation Research Core (DIRC) was our first major component of D&I infrastructure. DIRC’s mission is to accelerate the public health impact of clinical and health services research by increasing the engagement of investigators in later stages of translational research. The aims of DIRC are to advance D&I science and to develop and equip researchers with tools for D&I research. As a second formal component, the Washington University Institute for Public Health has provided significant support for D&I research through pilot projects and a small grants program. In a third set of formal programs, two R25 training grants (one in mental health and one in cancer) support post-doctoral scholars for intensive training and mentoring in D&I science. Finally, our team coordinates closely with D&I functions within research centers across the university. We share a series of challenges and potential solutions. Conclusion Our experience in developing D&I research at Washington University in St. Louis shows how significant capacity can be built in a relatively short period of time. Many of our ideas and ingredients for success can be replicated, tailored, and improved upon by others

From Functional Analysis to CAD Modelling Based on Knowledge Transformation Driven by the Design Process

Part 5: Modelling for PLMInternational audienceMost of industries currently spend too much time to find information on past product design process. This considerably reduces the time it can devote to innovation. The authors assume that the design process meta-model seems very interesting for modelling the design rational and then for accelerating information retrieval. Indeed, the model of the design process partly supports every resources involved in decision making activities (i.e. who, what, when, why, where, how). The authors therefore propose the use of a MBE architecture for driving the product modelling based on the design process model. The UML activity diagrams and the IDEFØ meta-model are linked for supporting automatic generation ofproduct models using specific transformation knowledge. The CAD model is partly generated from the product functional analysis

A Comparison of Gene Expression Signatures from Breast Tumors and Breast Tissue Derived Cell Lines

Cell lines derived from human tumors have historically served as the primary experimental model system for exploration of tumor cell biology and pharmacology. Cell line studies, however, must be interpreted in the context of artifacts introduced by selection and establishment of cell lines in vitro. This complication has led to difficulty in the extrapolation of biology observed in cell lines to tumor biology in vivo. Modern genomic analysis tool like DNA microarrays and gene expression profiling now provide a platform for the systematic characterization and classification of both cell lines and tumor samples. Studies using clinical samples have begun to identify classes of tumors that appear both biologically and clinically unique as inferred from their distinctive patterns of expressed genes. In this review, we explore the relationships between patterns of gene expression in breast tumor derived cell lines to those from clinical tumor specimens. This analysis demonstrates that cell lines and tumor samples have distinctive gene expression patterns in common and underscores the need for careful assessment of the appropriateness of any given cell line as a model for a given tumor subtype

Phase II Investigations at Prehistoric and Rock Art Sites, Justiceburg Reservoir, Garza and Kent Counties, Texas Volume I

Phase II cultural resources investigations at the proposed Justiceburg Reservoir in Garza and Kent counties, Texas, were conducted by Prewitt and Associates, Inc. in 19881989. This report documents the archeological work at 62 prehistoric and aboriginal rock art sites and the geoarcheological study conducted as part of the Phase II work. Investigations at 48 prehistoric sites, including open campsites, rockshelters, lithic procurement sites, faunal localities, and rock art sites, resulted in complete National Register assessments; 9 campsites, the 2 rockshelters, and 6 rock art sites are considered to be eligible for listing on the National Register of Historic Places. Less-intensive investigations at 14 prehistoric sites yielded insufficient data for full National Register assessments. The geoarcheological study resulted in the formulation of a model of the geomorphic history of the project area. Of considerable importance is the recognition of a period of catastrophic flushing of alluvial sediments Within the Double Mountain ~ork valley during the middle Holocene, followed by late Holocene sedimentation and stabilization. This supports the concept of a dry middle Holocene Altitherrnal period and helps explain the biased archeological record in the project area. The prehistoric site investigations indicate that most of the archeological remains present at Justiceburg Reservoir date to the late Archaic and Late Prehistoric periods, a phenomenon noted in similar settings elsewhere in the Lower Plains. Of the open campsites assessed as eligible for listing on the National Register, four are classified as late Archaic (4500-2000 B.P.), two are classified as Late Prehistoric I (2000-1000 8.P.), and three are classified as Late Prehistoric II (1000 B.P. to evidence of European contact). The two investigated rockshelters contain evidence of Late Prehistoric I and II occupations. Due to the paucity of regional archeological data and the lack of a well-defined cultural chronology, only two of these sites can be assigned tentatively to recognized cultural complexes. Site 4lGR291 yielded ceramics and arrow points indicating a Palo Duro Complex occupation, ca. A.D. 500, while ceramics and a distinctive hearth associated with the upper component at 41KTS3 suggest a Garza Complex occupation, ca. A.D. 1600-1700. No evidence of European contact was found at any of the habitation sites, but three of the rock art sites contain historic Plains Indian iconography. The investigations at the prehistoric sites resulted in the formulation of a late Holocene cuItural sequence for the project area. Analyses of the various classes of archeological evidence (e.g., artifacts, features, faunal remains) revealed broad cultural patterns that appear to reflect significant changes in subsistence strategies through time. It is suggested that these changes are related to late Holocene environmental conditions and corresponding shifts in the resource base. It is further suggested that bison were the most important resource controlling late Holocene human adaptations in the Texas Lower Plains

Phase II Investigations at Prehistoric and Rock Art Sites, Justiceburg Reservoir, Garza and Kent Counties, Texas Volume I

Phase II cultural resources investigations at the proposed Justiceburg Reservoir in Garza and Kent counties, Texas, were conducted by Prewitt and Associates, Inc. in 19881989. This report documents the archeological work at 62 prehistoric and aboriginal rock art sites and the geoarcheological study conducted as part of the Phase II work. Investigations at 48 prehistoric sites, including open campsites, rockshelters, lithic procurement sites, faunal localities, and rock art sites, resulted in complete National Register assessments; 9 campsites, the 2 rockshelters, and 6 rock art sites are considered to be eligible for listing on the National Register of Historic Places. Less-intensive investigations at 14 prehistoric sites yielded insufficient data for full National Register assessments. The geoarcheological study resulted in the formulation of a model of the geomorphic history of the project area. Of considerable importance is the recognition of a period of catastrophic flushing of alluvial sediments Within the Double Mountain ~ork valley during the middle Holocene, followed by late Holocene sedimentation and stabilization. This supports the concept of a dry middle Holocene Altitherrnal period and helps explain the biased archeological record in the project area. The prehistoric site investigations indicate that most of the archeological remains present at Justiceburg Reservoir date to the late Archaic and Late Prehistoric periods, a phenomenon noted in similar settings elsewhere in the Lower Plains. Of the open campsites assessed as eligible for listing on the National Register, four are classified as late Archaic (4500-2000 B.P.), two are classified as Late Prehistoric I (2000-1000 8.P.), and three are classified as Late Prehistoric II (1000 B.P. to evidence of European contact). The two investigated rockshelters contain evidence of Late Prehistoric I and II occupations. Due to the paucity of regional archeological data and the lack of a well-defined cultural chronology, only two of these sites can be assigned tentatively to recognized cultural complexes. Site 4lGR291 yielded ceramics and arrow points indicating a Palo Duro Complex occupation, ca. A.D. 500, while ceramics and a distinctive hearth associated with the upper component at 41KTS3 suggest a Garza Complex occupation, ca. A.D. 1600-1700. No evidence of European contact was found at any of the habitation sites, but three of the rock art sites contain historic Plains Indian iconography. The investigations at the prehistoric sites resulted in the formulation of a late Holocene cuItural sequence for the project area. Analyses of the various classes of archeological evidence (e.g., artifacts, features, faunal remains) revealed broad cultural patterns that appear to reflect significant changes in subsistence strategies through time. It is suggested that these changes are related to late Holocene environmental conditions and corresponding shifts in the resource base. It is further suggested that bison were the most important resource controlling late Holocene human adaptations in the Texas Lower Plains

Phase II Investigations at Prehistoric and Rock Art Sites, Justiceburg Reservoir, Garza and Kent Counties, Texas Volume I

Phase II cultural resources investigations at the proposed Justiceburg Reservoir in Garza and Kent counties, Texas, were conducted by Prewitt and Associates, Inc. in 19881989. This report documents the archeological work at 62 prehistoric and aboriginal rock art sites and the geoarcheological study conducted as part of the Phase II work. Investigations at 48 prehistoric sites, including open campsites, rockshelters, lithic procurement sites, faunal localities, and rock art sites, resulted in complete National Register assessments; 9 campsites, the 2 rockshelters, and 6 rock art sites are considered to be eligible for listing on the National Register of Historic Places. Less-intensive investigations at 14 prehistoric sites yielded insufficient data for full National Register assessments. The geoarcheological study resulted in the formulation of a model of the geomorphic history of the project area. Of considerable importance is the recognition of a period of catastrophic flushing of alluvial sediments Within the Double Mountain ~ork valley during the middle Holocene, followed by late Holocene sedimentation and stabilization. This supports the concept of a dry middle Holocene Altitherrnal period and helps explain the biased archeological record in the project area. The prehistoric site investigations indicate that most of the archeological remains present at Justiceburg Reservoir date to the late Archaic and Late Prehistoric periods, a phenomenon noted in similar settings elsewhere in the Lower Plains. Of the open campsites assessed as eligible for listing on the National Register, four are classified as late Archaic (4500-2000 B.P.), two are classified as Late Prehistoric I (2000-1000 8.P.), and three are classified as Late Prehistoric II (1000 B.P. to evidence of European contact). The two investigated rockshelters contain evidence of Late Prehistoric I and II occupations. Due to the paucity of regional archeological data and the lack of a well-defined cultural chronology, only two of these sites can be assigned tentatively to recognized cultural complexes. Site 4lGR291 yielded ceramics and arrow points indicating a Palo Duro Complex occupation, ca. A.D. 500, while ceramics and a distinctive hearth associated with the upper component at 41KTS3 suggest a Garza Complex occupation, ca. A.D. 1600-1700. No evidence of European contact was found at any of the habitation sites, but three of the rock art sites contain historic Plains Indian iconography. The investigations at the prehistoric sites resulted in the formulation of a late Holocene cuItural sequence for the project area. Analyses of the various classes of archeological evidence (e.g., artifacts, features, faunal remains) revealed broad cultural patterns that appear to reflect significant changes in subsistence strategies through time. It is suggested that these changes are related to late Holocene environmental conditions and corresponding shifts in the resource base. It is further suggested that bison were the most important resource controlling late Holocene human adaptations in the Texas Lower Plains

Phase II Investigations at Prehistoric and Rock Art Sites, Justiceburg Reservoir, Garza and Kent Counties, Texas Volume I

Phase II cultural resources investigations at the proposed Justiceburg Reservoir in Garza and Kent counties, Texas, were conducted by Prewitt and Associates, Inc. in 19881989. This report documents the archeological work at 62 prehistoric and aboriginal rock art sites and the geoarcheological study conducted as part of the Phase II work. Investigations at 48 prehistoric sites, including open campsites, rockshelters, lithic procurement sites, faunal localities, and rock art sites, resulted in complete National Register assessments; 9 campsites, the 2 rockshelters, and 6 rock art sites are considered to be eligible for listing on the National Register of Historic Places. Less-intensive investigations at 14 prehistoric sites yielded insufficient data for full National Register assessments. The geoarcheological study resulted in the formulation of a model of the geomorphic history of the project area. Of considerable importance is the recognition of a period of catastrophic flushing of alluvial sediments Within the Double Mountain ~ork valley during the middle Holocene, followed by late Holocene sedimentation and stabilization. This supports the concept of a dry middle Holocene Altitherrnal period and helps explain the biased archeological record in the project area. The prehistoric site investigations indicate that most of the archeological remains present at Justiceburg Reservoir date to the late Archaic and Late Prehistoric periods, a phenomenon noted in similar settings elsewhere in the Lower Plains. Of the open campsites assessed as eligible for listing on the National Register, four are classified as late Archaic (4500-2000 B.P.), two are classified as Late Prehistoric I (2000-1000 8.P.), and three are classified as Late Prehistoric II (1000 B.P. to evidence of European contact). The two investigated rockshelters contain evidence of Late Prehistoric I and II occupations. Due to the paucity of regional archeological data and the lack of a well-defined cultural chronology, only two of these sites can be assigned tentatively to recognized cultural complexes. Site 4lGR291 yielded ceramics and arrow points indicating a Palo Duro Complex occupation, ca. A.D. 500, while ceramics and a distinctive hearth associated with the upper component at 41KTS3 suggest a Garza Complex occupation, ca. A.D. 1600-1700. No evidence of European contact was found at any of the habitation sites, but three of the rock art sites contain historic Plains Indian iconography. The investigations at the prehistoric sites resulted in the formulation of a late Holocene cuItural sequence for the project area. Analyses of the various classes of archeological evidence (e.g., artifacts, features, faunal remains) revealed broad cultural patterns that appear to reflect significant changes in subsistence strategies through time. It is suggested that these changes are related to late Holocene environmental conditions and corresponding shifts in the resource base. It is further suggested that bison were the most important resource controlling late Holocene human adaptations in the Texas Lower Plains